Reactive oxygen species generation through NADH oxidation by pterin derivatives
نویسندگان
چکیده
منابع مشابه
Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules*
Pterins, a family of heterocyclic compounds derived from 2-aminopteridin-4(1H)one, are widespread in living systems and participate in important biological functions, such as metabolic redox processes. Under UV-A excitation (320–400 nm), aromatic pterins (Pt) can generate reactive oxygen species (ROS), as a consequence of both energyand electrontransfer processes from their triplet excited stat...
متن کاملKetones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation.
Dietary protocols that increase serum levels of ketones, such as calorie restriction and the ketogenic diet, offer robust protection against a multitude of acute and chronic neurological diseases. The underlying mechanisms, however, remain unclear. Previous studies have suggested that the ketogenic diet may reduce free radical levels in the brain. Thus, one possibility is that ketones may media...
متن کاملReactive Oxygen Species Generation by Lunar Simulants
Introduction: The current interest in human exploration of the Moon and past experiences of Apollo astronauts has rekindled research into the harmful effects of Lunar dust on human health. While the mineralogical composition of lunar regolith has been well documented, other factors, such as partial melting due to space weathering, UV irradiation, and dryness may also contribute to the toxicity ...
متن کاملCuscuta campestris induces apoptosis by increasing reactive oxygen species generation in human leukemic cells
Objective: Cuscuta campestris or common dodder is a holoparasitic plant that has been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of C. campestris had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydr...
متن کاملCardiac mitochondria and reactive oxygen species generation.
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the electron transport chain and the proton motive force consisting of a membrane potential (ΔΨ) and a proton gradient (ΔpH). Several factors controllin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2008
ISSN: 0261-3166,1746-8272
DOI: 10.1093/nass/nrn287